陈进，三级教授/博导，东南大学兼职博导，江苏特聘教授（卫生检验学），南京医科大学第三届“优秀研究生导师”(2022年)。2001、2006年毕业于南京大学获学士、博士; 2005年德国Tech. Univ. Munich，访问博士生，2006年Humboldt research fellow; 2009年日本自然科学研究院, postdoc，2010年研究助理教授；2014年到校工作。长期从事生物分析和分子伴侣研究工作，近年来发表SCI论文70多篇，被引2000余次。2015-2017年获校特聘教授，省双创团队和青年科技人才托举工程，2018-2023年获校“优秀本科生导师”和“优秀指导教师”，以第一完成人获省分析测试协会科技奖二等奖和江苏医学科技奖三等奖。
研究方向：1. 纳米技术和生物医学应用；2. 蛋白稳态和分子识别； 3. 肿瘤分子诊断与新型给药体系研究；4. 病原微生物检测和消杀。
课题组成员：
博士生：蔡铃（2020级，东南大学联培，南医卫检）；N. Ahmed（2021级，MPH，North South University）; 乐冠楠（2022级，东南大学联培，南农动物医学）;
临床联培博士生：王昊、武亦娴
硕
生：2020级: 邵雪梅（在职MPH, 南医卫检）；2021级: 杨静（安医卫检推免），国际MPH学生：Moussa（Mali）
2022级: 李雨晴（安医卫检推免），李姮慧（MPH，重医），贾晓宇（MPH，安医）
2023级: 罗欢（西南医预防推免），李金焕（MPH，杭医卫检）
2024级: 马晓玉（新医预防推免）
长学制本科生：何佳铭；吴笑宇；陈鹏宇
已毕业学生：
硕士生：2020级: 朱馨怡（MPH，宁大预防，浙江CDC），裴巍（安医卫检推免，同济医学院），张李（MPH，安医卫检，安徽三甲医院）；
2019级: 周刘柱（南医卫检，苏州CDC），张嘉容（MPH，西南大学动物医学，浙江三甲医院）;
2018级: 朱萍（南医卫检，卫健委）；徐其兰（MPH，康达学院预防，上海CDC）；2017级：蔡铃 (转博)；2016级：宋翌琰（南医卫检，苏州三甲医院）；2015级：徐智慧（南医卫检，苏州CDC）
博士生：2020级，阮红杰（临床联培，主任医师）；2016级：俞心愉 (省血吸虫病防治研究所博士后)
国际MPH学生：2019级: Jeremiah (M.D., 长沙医学院)
博士后：R. Manikandan（PhD, University of Madras，印度）; 王军（博士，南京大学）
学术兼职：ISO/TC330国内技术对口工作组委员，司法鉴定所授权签字人，中国骆驼产业联盟专家委员会委员，江苏省生物医学工程协会专业委员会委员，AJPS, AROH, Burns & trauma, EEH, iMeta, Med Adv, MMR（卓越行动计划）等期刊青年编委；iLABMED科学编辑，《理化检验》青年编委，Chem. Eng. J., Anal. Chem.等50多种国际期刊审稿人。
本课题组每年招收2-4名研究生（学术/专业学位），欢迎具有医学（动物医学/病微），生物分析/生物材料或蛋白质科学等相关专业学生加入。
联系方式：南京市江宁区龙眠大道101号南医至诚楼；邮箱：jchen@njmu.edu.cn
近5年主要主持项目：
1. 江苏省高等学校自然科学研究重大项目，环境友好型多功能复合膜抗菌应用及机制研究，2023-2026，30万元，主持。
2. 国家自然科学基金联合基金（U1703118），新疆塔里木双峰驼血清免疫反应效应因子评价和结构生物学研究，2018-2020，主持，已结题。
3. 江苏省自然科学基金面上项目，构建可控微纳体系发展肿瘤标志物多元检测新方法，2018-2021，10万元，主持，已结题。
4. 江苏特聘教授基金（卫生检验学），2016-2019，100万元，主持，已结题。
近5年指导学生所获荣誉：
1. 研究生国家奖学金（2023年：李雨晴；2022年：裴巍，朱馨怡；2020年：朱萍，徐其兰；2019年：蔡铃；2018年：宋翌琰）；一等学业奖学金（19人次）；校扬子江药业奖学金（2023年：杨静）；东南大学博士二等学业奖学金：2021年，蔡铃
2. 2023年首届“高层次应用型公共卫生人才培养项目-腾讯奖学金”：朱馨怡
3. 大学生创新训练计划（国家级）3项（2017-2019年，15级卫检；2020-2022年，19级临床/天元班； 2023-2025年，22级临床/天元班）；
大学生创新训练计划（省级）1项（2022-2024年，20级卫检）
4. 江苏省优秀硕士学位论文（2023年：张嘉容；2022年：徐其兰）；
校优秀硕士学位论文（2019-2023：张嘉容/朱萍/徐其兰/蔡铃/宋翌琰/徐智慧）
5. 校学术之星硕士组：2023年第七届：第6名/裴巍，第9名/朱馨怡；2020年第五届：第8名/朱萍；2018年第三届：第2名/宋翌琰
6. 2023年第18届“挑战杯”全国大学生课外学术科技作品竞赛黑科技专项赛江苏省“恒星”级（省赛一等奖）1项（本科生）；“行星”级（省赛二等奖）1项（研究生）；
2021年第17届“挑战杯”全国大学生课外学术科技作品竞赛黑科技专项赛国赛“恒星”奖（国赛一等奖）；省赛一等奖2项（本科生）；
2019年第16届 “挑战杯”全国大学生课外学术科技作品竞赛省赛二等奖（本科/研究生）
7. 校百佳研究生/优秀共青团员（2019：蔡铃）；校研究生三好学生（2021-2024：李雨晴/贾晓宇/李姮慧/朱馨怡/裴巍/朱萍）；校研究生优秀毕业生（2019-2024：杨静/裴巍/朱馨怡/朱萍/徐其兰/蔡铃/宋翌琰）
指导本科生以第一作者发表学术论文:
1. Shi Y#, Chen J* et al. Electrospun antimicrobial polymeric nanofibers in wound dressings. Adv Polym Sci 2023, 291, 313. (IF=10.1)
2. 张萍（卫检）等, 基于功能化石墨烯的适配体生物传感器研究, 中国卫生检验杂志, 2016, 24, 3645.
近5年代表性论文：（#并列一作, *通讯）
49. Zhu X#, Li H#, Chen J* et al. ZnO nanoparticles encapsulated cellulose-lignin film for antibacterial and biodegradable food packaging. iScience, 2024, in press.
48. Yang J#, Luo H#, Zhu X, Cai L, Zhou L, Ruan H*, Chen J* Copper-doped bismuth oxychloride nanosheets assembled into sphere-like morphology for improved photocatalytic inactivation of drug-resistant bacteria. Sci Total Environ 2024, 912, 168916.
47. Xu Q#, Zhang L#, Liu Y, Cai L, Zhou L, Jiang H, Chen J* Encapsulating electrochemically generated MoS2 conjugated with chitosan oligosaccharide into electrospun nanofibrous scaffolds for improved near-infrared photothermal inactivation of bacteria. J Nanostruct Chem, 2024, 14, 137-151.
46. Cai L#, Yang J#, Shao X#, Zhu X, Zhang L, Liu Y, Chen J* et al. Copper-doped nanostructured MoS2 with distinct nanoscale morphology for efficient bacteria inactivation and catalytic degradation of antibiotics. J Environ Chem Eng, 2024, 12, 111537.
45. Sun Y, Zhou L, Ding Y, Liu C, Mao Z, Jiang Q, Chen J*, Chen F*, Cao Y* Fabrication of flexible electrospinning nano-fiber membrane for detection of respiratory tract transmission virus based on SERS. Talanta 2024, 266, 125127.
44. Cai L, Zhang L, Yang J, Zhu X, Wei W, Jiang H, Ji M, Chen J* Encapsulating antibiotic and protein-stabilized nano-silver into sandwich-structured electrospun nanofibrous scaffold for MRSA-infected wound treatment. ACS Appl Mater Interfaces 2023, 15, 42, 48978-48995.
43. Le G#, Li Y#, Cai L, Zhang L, Pei W, Zhu X, Xu S, Zhang J, Chen J* Lysozyme-based nanozyme encapsulated in double-network hydrogel for monitoring and repair of MRSA infected wounds. Chem Eng J 2023, 477, 146421.
42. Pei W#, Li Y#, Wu Y#, Wu Y#, Cai L, Wang SZ, Wang SL, Chen J* A tumoricidal lipoprotein complex electrostatically stabilized on mesoporous silica as nanotherapeutics and nanoadjuvant for potentiating immunotherapy of triple negative breast cancer. Adv Funct Mater 2023, 2308117.
41. Cai L#, Zhu X#, Ruan H#, Yang J, Wei W, Wu Y, Zhou L, Jiang H, Ji M, Chen J* Curcumin-stabilized silver nanoparticles encapsulated in biocompatible electrospun nanofibrous scaffold for sustained eradication of drug-resistant bacteria. J Hazard Mater, 2023, 452, 131290.
40. Zhang L#, Yang J#, Zhu X#, Jia X#, Liu Y, Cai L, Wu Y*, Ruan H*, Chen J* Electrospun nanofibrous membranes loaded with IR780 conjugated MoS2-nanosheet for dual-mode photodynamic/photothermal inactivation of drug-resistant bacteria. Environ Technol & Innov, 2023, 30, 103098.
39. Zhou L#, Zhu X#, Yang J#, Cai L, Zhang L, Jiang H, Ruan H*, Chen J* Deciphering photoactive species-directed antibacterial mechanism of bismuth oxychloride with nanoscale thickness-modulated photocatalytic activities. J Environ Manage, 2023, 333, 117411.
38. Zhu X#, Li H#, Zhou L, Jiang H, Ji M, Chen J* Evaluation of the gut microbiome alterations in healthy rats after dietary exposure to different synthetic ZnO nanoparticles. Life Sci., 2023, 312, 121250.
37. Zhu P#, Cai L#, Liu Q#, Feng S#, Ruan H, Zhang L, Zhou L, Jiang H, Wang H*, Wang J*, Chen J* One-pot synthesis of α-Linolenic acid nanoemulsion-templated drug-loaded silica mesocomposites as efficient bactericide against drug-resistant Mycobacterium Tuberculosis. Eur J Pharm Sci, 2022, 176, 106261.
36. Yang X#, Wen X#, Dai J, Chen Y, Ding W, Wang J, Gu X, Zhang X, Chen J, Sutliff R, Emory S.*, Ruan G.* Probing the intracellular delivery of nanoparticles into hard-to-transfect cells. ACS Nano, 2022,16(6), 8751-8765.
35. Pei W#, Cai L#, Gong X#, Zhang L#, Zhang J, Zhu P, Jiang H, Wang C, Wang S.*, Chen J* Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy. Mater Today Bio, 2022, 15, 100272.
34. Zhu X#, Wang J#, Cai L#, Wu Y#, Ji M, Jiang H, Chen J* Dissection of antibacterial mechanism of zinc oxide nanoparticles with manipulable nanoscale morphologies. J Hazard Mater, 2022, 430, 128436.
33. Zhang J#, Xu Q#, Pei W#, Jiang H, Chen J* Desolvation-induced formation of recombinant camel serum albumin-based nanocomposite for glutathione colorimetric determination. Sensor Actuat B-Chem, 2022, 357, 131417.
32.Wang J, Zhu X, Li C, Pei W, Cai L, Ni M, He J, Jiang H, Chen J.* Efficient exosome extraction through superparamagnetic iron oxides conjugation for the targeted delivery in rat brain. Mater today chem, 2022, 23, 100637.
31.Zhang J#, Xu Q#, Pei W#, Cai L, Yu X, Jiang H, Chen J.* Self-assembled recombinant camel serum albumin nanoparticles-encapsulated hemin with peroxidase-like activity for colorimetric detection of hydrogen peroxide and glucose. Int J Biol Macromol. 2021, 193, 2103-2112.
30.Wang J#, Zhu X#, Pei W#, Zhou L, Cai L, Jiang H, Chen J.* ZnO nanocluster loaded superparamagnetic iron oxide nanocomposites as recyclable antibacterial agent. Colloid Interface Sci Commun, 2021, 45, 100510.
29.Zhang J#, Sun H#, Pei W, Jiang H., Chen J.* Nanobody-based immunosensing methods for safeguarding public health. J Biomed Res. 2021, 35(4), 318-326.
28. Jiang Q#, Li D#, Liu Y, Mao Z, Yu Y, Zhu P, Xu Q, Sun Y, Hu L, Wang J, Chen J.*, Chen F*, Cao Y* Recyclable and green AuBPs@MoS2@tinfoil box for high throughput SERS tracking of diquat in complex compounds. Sensor Actuat B-Chem, 2021, 344, 130290.
27 Cai L#, Zhu P #, Huan F, Wang J, Zhou L, Jiang H, Ji M, Chen J.* Toxicity-attenuated mesoporous silica Schiff-base bonded anticancer drug complexes for chemotherapy of drug resistant cancer. Colloids Surf B: Biointerfaces, 2021, 205, 111839.
26 Zhou L#, Cai L#, Zhang L, Wang J, Jiang H, Ruan H, Wu Y*, Feng S*, Chen J.* Electrospun chitosan oligosaccharide/polycaprolactone nanofibers loaded with wound-healing compounds as antibacterial dressings. Int J Biol Macromol, 2021, 183, 1145-1154.
25. Yang F#, Zhou L#, Dong X, Zhang W, Gao S, Wang X, Li L, Yu C, Wang Q, Yuan A, Chen J.* Visible-light-responsive nanofibrous α-Fe2O3 integrated FeOx cluster-templated siliceous microsheet for rapid catalytic phenol removal and enhanced antibacterial activity. ACS AMI, 2021, 13, 19803-19815.
24.Xu Q#, Liu Y#, Cai L#, Cao Y, Chen F, Zhou L, Zhu P, Jiang H, Jiang Q, Sun Y, Chen J.* A green electrolysis of silver-decorated MoS2 nanocomposite with an enhanced antibacterial effect and low cytotoxicity. Nanoscale Adv, 2021, 3, 3460-3469. (Front cover)
23. Zhu P#, Xu Z#, Cai L, Chen J.* Multifunctional porphyrin iron grafted mesoporous silica composites for drug delivery, dye degradation and colorimetric detection of hydrogen peroxide. Nanoscale Res Lett, 2021, 16, 41.
22. Cai L#, Huang Y#, Duan Y#, Liu Q#, Xu Q, Jia J, Wang J, Tong Q, Luo P, Wen Y, Peng L, Wu Q, Hang X, Jiang H, Zhu P, Yang Y, Zhou B, Zeng L, Bi H*, Chen J.* Schiff-Base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes. Nano Res, 2021, 14, 2735-2748. (Back cover)
21. Song Y#, Zhu P#, Xu Z, Chen J.* Dual-responsive dual-drug loaded bioinspired polydopamine nanospheres as efficient therapeutic nanoplatform against drug-resistant cancer cells. ACS Appl Bio Mater, 2020, 3, 5730-5740 (Back cover)
20. Yang F#*, Zhou L#, Gao S, Wang X, Chen J.*, Yuan A, Ang E* Combining two active states of FeOx in-situ in molecular sieve to deliver enhanced catalytic activity via creating special configuration and synergy. J Alloys Comp, 2020, 844, 156137.
19. Song Y#, Cai L#, Tian Z, Wu Y*, Chen J.* Phytochemical curcumin co-formulated silver-decorated melanin-like polydopamine/mesoporous silica composite with improved antibacterial and chemotherapeutic effect against drug-resistant cancer cells. ACS Omega. 2020, 5, 15083-15094.
18. Yu X#, Xu Q#, Wu Y, Jiang H, Wei W, Zulipikaer A, Guo Y, Jirimutu, Chen J.* Nanobodies derived from Camelids represent versatile biomolecules for biomedical applications. Biomater Sci, 2020, 8, 3559-3573. (Back cover)
17. Xu Q#, Zhu P#, Zhang J#, Liu Y, Cai L, Jiang H, Ji M, Chen J.* Electrochemical formation of distinct nanostructured MoS2 with altered antibacterial activity. Mater. Lett. 2020, 127809.
16. Zhu P#, Zhou L#, Song Y, Cai L, Ji M, Wang J, Ruan G, Chen J.* Encapsulating insoluble antifungal drugs into oleic acid-modified silica mesocomposites with enhanced fungicidal activity. J Mater Chem B, 2020, 8, 4899-4907.
15. Yu X#, Xu Z#, Wang X, Xu Q, Chen J.* Bactrian camel serum albumins-based nanocomposite as versatile biocargo for drug delivery, biocatalysis and detection of hydrogen peroxide. Mater Sci Eng C, 2020, 109, 110627.
14. Yu X#, Xieripu A#, Xu Q#, Song Y, Cai L, Chen J.* GSH-responsive curcumin/doxorubicin encapsulated Bactrian camel serum albumin nanocomposites with synergistic effect against lung cancer cells. J Biomed Res, 2020, 34 (1), 54-66.
13. Yu X, Wu Y*, Zhang J, Jirimutu, Zulipikaer A, Chen J.* Pre-evaluation of Humoral Immune Response of Bactrian Camels by the Quantification of Th2 Cytokines using Real-time PCR. J Biomed Res, 2020, 34(5), 387-394.
12. Cai L#, Qin X#, Xu Z, Song Y, Jiang H, Wu Y, Ruan H, Chen J.* Comparison of cytotoxicity evaluation of anticancer drugs between real-time cell analysis and CCK-8 method. ACS Omega. 2019, 4, 12036-12042.
11. Xu E, Yang H, Wu L*, Chen J, Wei W*, Liu Y, Liu S. Label-free poly(ADP-ribose) polymerase-1 activity assay based on perpendicular orientated mesoporous silica films. Sensor Actuat B-Chem. 2019, 294, 185-191.
10. Wang C.#, Li Y.#, Xu E., Zhou Q., Chen J., Wei W.*, Liu Y., Liu S. A label-free PFP-based photoelectrochemical biosensor for highly sensitive detection of PARP-1 activity. Biosens Bioelectron, 2019, 138, 111308
9. Song Y.#, Zhu P.#, Wu Y.#, Tan L., Wei W., Liu S., Huang Q., Chen J.* Epsilon-poly-L-lysine decorated ordered mesoporous silica contributes to the synergistic antifungal effect and enhanced solubility of a lipophilic drug. Mater Sci Eng C, 2019, 99, 231-240.
8. Wei M.#, Wang C.#, Xu E., Chen J.*, Xu X., Wei W.*, Liu S. A simple and sensitive electrochemiluminescence aptasensor for determination of ochratoxin A based on a nicking endonuclease-powered DNA walking machine. Food Chem, 2019, 282, 141-146.
7. Xu Z.#, Cai L.#, Jiang H., Wen Y., Peng L., Wu Y., Chen J.* Real-time cell analysis of the cytotoxicity of a pH-responsive drug-delivery matrix based on mesoporous silica materials functionalized with ferrocenecarboxylic acid. Anal Chim Acta, 2019, 1051, 138-146.
6. Yang F.#, Song Y.#, Cai L.#, Zhou S., Chen J.*, Kong, Y.*. Enriched Ag nanospecies interspersed nanoporous siliceous antibacterial agent. ChemistrySelect 2018, 3, 10255-10258.
5. Liu Y.#, Xu X.#, Yang H., Xu E., Wu S., Wei W.*, Chen J.* Analysis of poly(ADP-ribose) polymerase-1 by enzyme-initiated auto-PARylation controlled aggregation of hemin-graphene nanocomposites. Analyst, 2018, 143, 2501-2507.
4. Xu Z.#, Song Y.#, Jiang H., Kong Y., Li X., Chen J.*, Wu Y.* Regeneration of arrayed gold microelectrodes equipped for a real-time cell analyzer. J Vis Exp, 2018, 133, e56250.
3. Song Y., Jiang H., Shi X., Chen J.*, Wu Y.*, Wei W.*, Detection of lead using a sensitive anodic stripping voltammetric method based on composite mesoporous silica/bismuth oxychloride modified electrode. ChemistrySelect, 2018, 3, 2423-2429.
2. Song Y., Jiang H., Wang B., Kong Y., Chen J.* Silver incorporated mussel-inspired polydopamine coatings on mesoporous silica as an efficient nanocatalyst and antimicrobial agent. ACS Appl Mater Interfaces, 2018, 10, 1792-1801.
1. Song Y., Chen J.*, et al. Multifunctional bismuth oxychloride/mesoporous silica composites for photocatalysis, anti-bacterial test and simultaneous stripping analysis of heavy metals. ACS Omega, 2018, 3, 973-981.